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Three separate scientific studies conducted by Asst. Prof. Kübra Çiğdem Pekkoç Uyanık, a faculty member in the Department of Medical Biology at Haliç University Faculty of Medicine, focusing on epilepsy and Attention-Deficit/Hyperactivity Disorder (ADHD), have been published in international academic journals.
Asst. Prof. Pekkoç’s study entitled “Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy,” which examines the relationship between antiepileptic drug response in patients with epilepsy and genetic variations in voltage-gated potassium channel genes, was published in Pharmaceuticals, a journal with an impact factor of 5.7. The research, published in a journal ranked in the Q1 category according to Scopus and SCIE (Web of Science), revealed that certain combinations of genetic variations in the KCNV2 gene were more frequently observed in patients who did not respond adequately to antiepileptic medications. These findings contribute to research into genetic markers for personalized approaches to epilepsy treatment.
The second study, entitled “Role of Synaptosomal-Associated Protein 25 Gene in Clinical Response to Methylphenidate Among Turkish Pediatric ADHD Cohort,” was published in Children. The research, published in a journal ranked in the Q1 category according to Scopus and SCIE (Web of Science), investigated the relationship between response to methylphenidate treatment and genetic variations in the SNAP-25 gene among children and adolescents diagnosed with ADHD. The findings revealed a significant association between the T allele of the rs362998 variant of the gene and a positive treatment response. In addition, a previously unreported genetic variant was identified in the 3′ untranslated region (3′UTR) of the SNAP-25 gene.
Asst. Prof. Pekkoç’s third study, entitled “Genetic Variations in Neuroinflammatory Chemokine Receptor Genes in Patients with Epilepsy: An Exploratory Study,” examined genetic variations in chemokine receptor genes involved in neuroinflammatory processes in patients with epilepsy. The study was published in International Journal of Molecular Sciences, a journal with an impact factor of 5.6. The research, published in a journal ranked in the Q1 category according to Scopus and SCIE (Web of Science), demonstrated strong linkage disequilibrium between the rs179998 and rs1800023 variants of the CCR5 gene. The study contributes to a better understanding of neuroinflammatory mechanisms and genetic variations in epilepsy.
We congratulate our faculty member on the publication of these three scientific studies and wish her continued success.
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